Ryan Williams – RB (knee) Questionable for beginning of the season. Rashard Mendenhall has earned the starting role in his absence, and even when healthy Williams is at best challenging for a shared role.
Mike Johnson – RT (ankle, broken fibula) Out for season. Offensive line depth becomes a problem as Lamar Holmes becomes the starter. Further injuries will affect RB Steven Jackson and QB Matt Ryan.
Dennis Pitta – TE (fractured/dislocated hip) Out for season. Ed Dickson becomes the top TE and the third receiving option behind WR Torrey Smith and RB Ray Rice. However…
Ed Dickson – TE (hamstring) Out until week one, possibly longer. Visanthe Shiancoe and Dallas Clark signed to compete for the starting role while he is out. QB Joe Flacco has few reliable receiving options beyond Rice, Smith, and the TEs.
E.J. Manuel – QB (knee) Questionable for week one. Kevin Kolb gets valuable preseason work in his absence and may take the starting role because of it. He’ll be the starter as long as Manuel is unavailable.
Nate Livings – G (knee) Expected back between weeks 1-3. Players behind him on the depth chart are injured so Livings missing any time creates serious offensive line problems for QB Tony Romo and RB DeMarco Murray.
J.D. Walton – C (ankle) Out until at least late October, possibly all season. Dan Koppen was signed to replace him but he is out for the season (ACL). Peyton Manning will suffer the most from any deficiencies on the offensive line.
Green Bay Packers
Bryan Bulaga – LT (ACL) Out for season. Major injury considering Buluga protects quarterback Aaron Rodgers’ blind side. If rookie David Bakhtiari can step up the effect may be minimized, but Rodgers may see plenty more sacks in 2013.
Dwayne Allen – TE (foot) Questionable for week one. Colby Fleener (concussion, probable for week one) will see more targets in the passing game while Allen is out.
Blaine Gabbert – QB (thumb) He is listed as questionable for the start of the season but Monday morning he was named the starter for week one. Clearly the coaching staff expects him to be ready despite his broken thumb.
Dustin Keller – TE (knee) Out for season. Now no Miami TE is worth owning, WRs and RBs become slightly more valuable by default, and QB Ryan Tannehill takes a small hit to his value as he loses his security blanket and a big redzone target.
Jermone Felton – FB (appendectomy) Questionable for week one. As the lead blocker for RB Adrian Peterson his missing any game time means AP may have a few slower weeks at the start of the season.
New England Patriots
Rob Gronkowski – TE (forearm, back) Undetermined timetable. The latest news on Gronk is that he’s selling his Tampa Bay mansion. The Patriots have been particularly tight lipped about the status of their superstar TE, which is not surprising but extremely frustrating. His absence has allowed for the emergence of Zach Sudfeld, who has fantastic upside as the starting New England TE. He will retain most of that value even as the #2 guy when the Patriots line up in two-TE sets with both Gronkowski and Sufeld.
New Orleans Saints
Joe Morgan – WR (knee) Out for season. One of the backup WR roles will now be filled by Kenny Stills and/or Nick Toon.
New York Jets
Santonio Holmes – WR (foot) “Week to week.” He hasn’t practiced all season and won’t set a date or even a goal for his return. Jeremy Kerley and Stephen Hill have emerged as the starters in his absence along with the signing of veteran Braylon Edwards.
Jared Veldheer – LT (triceps) Out for season. Protecting QB Matt Flynn appears nearly impossible and opening running lanes for RB Darren McFadden becomes more difficult. Alex Barron is not a quality replacement.
Jeremy Maclin – WR (ACL) Out for season. DeSean Jackson becomes far and away the top WR while Jason Avant and Riley Cooper will compete for the second starting position but both will likely see time in the wide open offense.
Heath Miller – TE (ACL) Expected to come off PUP list, likely out at least several games. Injured in late 2012 he is aiming for a return in early 2013. In the meantime the backup TE and slot WRs will see more targets except…
Matt Spaeth – TE (foot) Out indefinitely and Plaxico Burress – WR (rotator cuff) Out for season. The two most likely veterans to step up in place of Miller won’t be able to for some time. Spaeth is recovering from surgery and his recovery status hasn’t been determined, but he will likely be unavailable until Miller returns, if not longer. WRs Jerricho Cotchery and rookie Markus Wheaton will be called upon to contribute in the passing game.
San Diego Chargers
Danario Alexander – WR (ACL) Out for season. Eddie Royal – WR (lung) and Malcom Floyd (knee) Both questionable for week one. A collection of injuries leaves Vincent Brown and rookie Keenan Allen as the only unscathed WRs.
San Francisco 49ers
Michael Crabtree – WR (Achilles) Out until at least mid-November. The biggest beneficiary from him missing half the season will be TE Vernon Davis who has been lining up all over the field as a receiving option.
Percy Harvin – WR (hip) Expected to miss at least 12 weeks (eleven games and bye week). Jermaine Keasre has stepped up nicely filling in for Harvin in the receiving and return aspects of the game.
Teams with no significant injuries: Carolina Panthers, Chicago Bears, Cleveland Browns, Cincinnati Bengals, Detroit Lions, Houston Texans, Kansas City Chiefs, New York Giants, St. Louis Rams, Tampa Bay Buccaneers, Tennessee Titans, and Washington Redskins.